SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Project area A includes all projects that study Effectors and Mediators that act on the cells of the vessel wall. These are: 

A3: Augustin 
Role of the Angiopoietin/Tie system in controlling vascular morphogenesis and homeostasis

A6: Fleming
The Cytochrome P450/soluble expoide hydrolase axis in angiogenic endothelial cell signalling and vascular differentiation

A7: Fischer
The role of Notch ligands during blood vessel development

A9: Schneider
Mechanism controlling the transition from quiescent to activated endothelium by exocytosis of Weibel-Palade bodies triggered by tumor cells

A10: Dimmeler
Role of shear stress-induced microRNAs in vessel maturation

Project area B includes all projects that study Cellular Responses of the cells of the vessel wall. These are: 

B1: Goerdt/Géraud
Liver-specific vascular differentiation and function

B2: Schorpp-Kistner/Angel
Role of Junb and Junb target genes in vascular morphogenesis and homeostasis 

B6: Wieland
Characterization of Nucleoside Diphosphate Kinase B as a novel regulator of angiogenesis

B7: Liebner
Molecular analysis of the Wnt/β-catenin and sonic hedgehog pathway in endothelial differentiation and remodeling

Project area C includes all projects that study Cellular and Systemic Interactions between the cells of the vessel wall. These are:

C1: Reiss/Plate
Role of Angiopoietins in brain vascular homeostasis

C5: Korff
Regulation of the smooth muscle cell phenotype switch during remodeling processes of arteries and veins

C6: Hecker
Endothelial cell-platelet-leukocyte interaction in vascular remodeling

C7: Offermanns/Wettschureck
Mechanisms regulating vascular smooth muscle cell differentiation

C8: Stainier
Role of the Meis2 homebox transcription factor in endocardial cell differentiation and function

Project area Z - Core Projects

Z1: Komljenovic
Non-invasive assessment of tissue micro-morphology, vessel function and cell migration in vivo with contrast-enhanced MRI, VCT and sonography and hybrid imaging

Z5: Kroll
The zebrafish as a model organism to study vascular differentiation and remodeling