SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

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Prof. Dr. Stefan Offermann and
Prof. Dr. Nina Wettschureck

Max-Planck-Institut für Herz- und Lungenforschung
Abteilung Pharmakologie
Ludwigstr. 43
D-61231 Bad Nauheim

Phone: 0049 (0)6032 705 1214

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C7: Mechanisms regulating vascular smooth muscle cell differentiation
Vascular remodeling processes in response to changes in haemodynamics or to injury involve dedifferentiation and redifferentiation of vascular smooth muscle cells (SMCs). How changes in the differentiation state of VSMCs are regulated is poorly understood. The aim of this project is to better understand how G-protein-coupled receptors regulate VSMC differentiation states and to characterize the role of the endothelium in maintaining and changing VSMC differentiation. Fate-mapping approaches using genetic tools will be employed to better understand the origin of smooth muscle marker-positive cells in various vascular pathologies.

Signalling pathways in activated platelets. ADP, adenosine diphosphate; DAG, diacyl glycerol;
Fb, fibrinogen, GP-IIb/IIIa, glycoprotein IIb/IIIa; IP3, inositol-1,4,5-trisphosphate; PKC, protein kinase C;
PLC-b, b-isoforms of phospholipase C; TXA2, thromboxane A2.


Last update: July 2013