SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Concluding meeting 2017
General Information
Graduate school
Scientific journals
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Publications of the Principal Investigators of the SFB/TR23 since 2009



Garg J, Feng Y, Jansen SR, Friedrich J, Lezoualc'h F, Schmidt M, Wieland T.
Catecholamines facilitate VEGF-dependent angiogenesis via β2-adrenoceptor-induced Epac1 and PKA activation.
Oncotarget. [Epub ahead of print], 2017 (Project B6)

Wieland E*, Rodriguez-Vita J*, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A.
Endothelial Notch1 activity facilitates metastasis.
Cancer Cell. 31(3):355-367, 2017 (Projects A7, C6)



Shalini Gross, Kavi Devraj, Yuxi Feng, Jadranka Macas, Stefan Liebner and Thomas Wieland.
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
J Cereb Blood Flow Metab, pii: 0271678X16669365. [Epub ahead of print], 2016. (Projects B6, B7)

Carmen Viski, Courtney König, Magdalena Kijewska, Carolin Mogler, Clare M. Isacke and Hellmut G. Augustin.
Endosialin-Expressing Pericytes Promote Metastatic Dissemination.
Cancer Res, 76:5313-25, 2016. (Project A3)

Lukas Goertz*, Stefan W. Schneider*, Anna Desch, Frank Thomas Mayer, Julian Koett, Kai Nowak, Ioannis Karampinis, Michael K. Bohlmann, Viktor Umansky, Alexander T. Bauer.
Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis.
Oncotarget, doi: 10.18632/oncotarget.11832. [Epub ahead of print], 2016. (Project A9)

Johannes Eschrich, Ralph Meyer, Hanna Kuk, Andreas H. Wagner, Thomas Noppeney, Sebastian Debus, Markus Hecker, Thomas Korff.
Varicose remodeling of veins is suppressed by HMG-CoA reductase inhibitors.
J Am Heart Assoc., 5: e002405, 2016. (Projects C5, C6)

Hannes Schröder, Dorde Komljenovic, Markus Hecker, Thomas Korff.
Transdermal drug targeting and functional imaging of tumor blood vessels in the mouse auricle.
FASEB J. 30:923-32. doi: 10.1096/fj.15-279240, 2016. (Projects C5, C6, Z1)

Alexander Scholz , Patrick N Harter, Sebastian Cremer, Burak H Yalcin, Stefanie Gurnik, Maiko Yamaji, Mariangela Di Tacchio, Kathleen Sommer, Peter Baumgarten, Oliver Bähr, Joachim P Steinbach, Jörg Trojan, Martin Glas, Ulrich Herrlinger, Dietmar Krex, Matthias Meinhardt, Astrid Weyerbrock, Marco Timmer, Roland Goldbrunner, Martina Deckert, Christian Braun, Jens Schittenhelm, Jochen T Frueh, Evelyn Ullrich, Michel Mittelbronn, Karl H Plate, Yvonne Reiss.
Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma.
EMBO Mol Med., 8:39-57, 2016. (Project C1)



Kristin Kiesow, Katrin Bennewitz, Laura Gutiérrez Miranda, Sandra J. Stoll, Bettina Hartenstein, Peter Angel, Jens Kroll and Marina Schorpp-Kistner.
Junb controls lymphatic vascular development in zebrafish via miR-182.
Scientific Reports, 5, 15007 EP , 2015. (Projects B2, Z5)

Yang WJ, Hu J, Uemura A, Tetzlaff F, Augustin HG, Fischer A .
Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis.
EMBO Mol Med, Oct;7(10):1267-84, 2015 (Projects A7 and A3)

Thomas Wieland and Paul V. Attwood.
Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease
Front. Pharmacol., doi: 10.3389/fphar.2015.00173; 21 August 2015. (Project B6)

Zhou X-B,* Feng Y-X,* Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T.
Nucleoside Diphosphate Kinase B–Activated Intermediate Conductance Potassium Channels Are Critical for Neointima Formation in Mouse Carotid Arteries
Arterioscler Thromb Vasc Biol. 35:1852-61, 2015. (Project B6)

Schulz GB, Wieland E, Wüstehube-Lausch J, Boulday G, Moll I, Tournier-Lasserve E, Fischer A.
Cerebral cavernous malformation-1 protein controls DLL4-Notch3 signaling between the endothelium and pericytes.
Stroke. 346(5):1337-1343, 2015 (Project A7)

Bauer AT, Suckau J, Frank K, Desch A, Goertz L, Wagner AH, Hecker M, Goerge T, Umansky L, Beckhove P, Utikal J, Gorzelanny C, Diaz-Valdes N, Umansky V, Schneider SW.
von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans.
Blood. 125:3153-3163, 2015. (Projects A9, C6)

Klose R*, Berger C*, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A .
Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis.
Cardiovasc Res. 107(1):153-163, 2015 (Projects A3, A7)

Qiu Y, Zhao D, Butenschön VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y.
Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina.
Acta Diabetol. Apr 23, 2015. [Epub ahead of print] (Projects A9, B6)

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T.
Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro.
FASEB J. Apr 9. pii: fj.14-267633, 2015. [Epub ahead of print] (Projects A3, C5, C6)

Wöltje K*, Jabs M*, Fischer A.
Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.
PLoS One, 10(3):e0120547, 2015 (Project A7)

Teichert M, Stumpf C, Booken N, Wobser M, Nashan D, Hallermann C, Mogler C, Müller CS, Becker JC, Moritz RK, Andrulis M, Nicolay JP, Goerdt S, Thomas M, Klemke CD, Augustin HG, Felcht M.
Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis.
Exp Dermatol, Mar 16. doi: 10.1111/exd.12688, 2015. [Epub ahead of print] (Projects A3, B1)

Yang Y, Gorzelanny C, Bauer AT, Halter N, Komljenovic D, Bäuerle T, Borsig L, Roblek M and Schneider SW.
Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity
Oncogene, March 9. doi:10.1038/onc.2015.40, 2015. [Epub ahead of print] (Projects A9, Z1)

Möller K, Adolph O, Koffler J, Elrod J, Popa M, Ghosh S, Schwarz M, Schwale C, Grässle S, Huck V, Bruehl C, Wieland T, Schneider SW, Nobiling R, Wagner AH, Hecker M.
Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells.
Thromb Haemost. 2015 Jan 22;113(4). [Epub ahead of print] (Projects A9, B6, C6)

Mogler C, Wieland M, König C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG.
Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage.
EMBO Mol Med, 7: 332-8, 2015 (Projects A3, Z1)

Herberich SH*, Klose R*, Moll I, Yang WJ, Wüstehube- Lausch J, Fischer A.
ANKS1B interacts with the cerebral cavernous malformation protein-1 and controls endothelial permeability but not sprouting angiogenesis.
PLoS One, 10(12):e0145304, 2015 (Project A7)

Schäker K, Bartsch S, Patry C, Stoll SJ, Hillebrands JL, Wieland T, Kroll J.
The bipartite rac1 Guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (elmo1/dock180) protects endothelial cells from apoptosis in blood vessel development.
J Biol Chem. 290(10):6408-18, 2015. (Projects B6, Z5)



Arnold C, Feldner A, Pfisterer L, Hödebeck M, Troidl K, Genové G, Wieland T, Hecker M, Korff T.
RGS5 promotes arterial growth during arteriogenesis.
EMBO Mol Med, 6(8):1075-89. , 2014. (Projects B6, C5, C6)

Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Neumann A, Géraud C, Arnold B, Rohr K, Komljenovic D, Schirmacher P, Goerdt S, Augustin H.
An inducible hepatocellular carcinoma model for preclinical evaluation of anti-angiogenic therapy in adult mice
Cancer Research, 74(15):4157-69, 2014. (ProjectsA3, B1, Z1)

Hödebeck M, Scherer C, Wagner AH, Hecker M, Korff T.
TonEBP/NFAT5 regulates ACTBL2 expression in biomechanically activated vascular smooth muscle cells.
Front Physiol. Dec 3;5:467. doi: 10.3389/fphys.2014.00467. eCollection 2014. (Projects C5, C6)

Pfisterer L, Meyer R, Feldner A, Drews O, Hecker M, Korff T.
Bortezomib protects from varicose-like venous remodeling.
FASEB J., 28(8):3518-27, 2014. (Projects C5, C6)

Pfisterer L, König G, Hecker M, Korff T.
Pathogenesis of varicose veins - lessons from biomechanics.
Vasa., 43:88-99, 2014. (Projects C5, C6)

Woik N, Dietz CT, Schäker K, Kroll J.
Kelch-like ECT2 interacting protein KLEIP regulates late stage pulmonary maturation via Hif-2α.
Dis.Model.Mech., in 7(6):683-92, 2014. (Project Z5)

Grassle S, Huck V, Pappelbaum KI, Gorzelanny C, Aponte-Santamaria C, Baldauf C, Gräter F, Schneppenheim R, Obser T, Schneider SW.
von Willebrand factor directly interacts with DNA from neutrophil extracellular traps.
Arterioscler Thromb Vasc Biol. 34(7):1382-9, 2014. (Project A9)

Feng Y, Gross S, Wolf NM, Butenschön VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes HP, Wieland T.
Nucleoside diphosphate kinase B regulates angiogenesis through modulation of vascular endothelial growth factor receptor type 2 and endothelial adherens junction proteins.
Arterioscler Thromb Vasc Biol. 34(10):2292-300, 2014. (Projects B6, B7, Z5)

Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T.
EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells.
Thromb Haemost. 112(1):151-63, 2014(Projects B7, C5, C6)

Manavski Y, Carmona G, Bennewitz K, Tang Z, Zhang F, Sakurai A, Zeiher AM, Gutkind JS, Li X, Kroll J, Dimmeler S, Chavakis E.
Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis.
Basic Res Cardiol. 109(2): 404, 2014. (Projects A2, A10, Z5)

Scherer C, Pfisterer L, Wagner AH, Hödebeck M, Cattaruzza M, Hecker M, Korff T.
Arterial wall stress controls NFAT5 activity in vascular smooth muscle cells.
J Am Heart Assoc. 3(2):e000626,2014. (C5)

Huck V, Schneider MF, Gorzelanny C, Schneider SW.
The various states of von Willebrand factor and their function in physiology and pathophysiology.
Thromb Haemost. 111(4):598-609, 2014. (Project A9)

Wagner AH, Schwarz M, König G, Hecker M.
Role of platelet CD40 ligand for endothelial cell-monocyte interaction in the presence of flow.
Korea-Aust Rheol J. Nov;26(4):405-8, 2014. (Project C6)



Del Galdo S, Vettel C, Heringdorf DM, Wieland T.
The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis.
Cell Signal. 25(12):2478-84, 2013. (Project B6)

Schröder HM, Hoffmann SC, Hecker M, Korff T, Ludwig T.
The tetraspanin network modulates MT1-MMP cell surface trafficking.
Int J Biochem Cell Biol. , 45:1133-44, 2013. (Projects C5, C6)

Korff T, Pfisterer L, Schorpp-Kistner M.
miR-663 and the miRaculous vascular smooth muscle phenotypic switch.
Circ Res. , 113:1102-5, 2013. (Projects B2, C5)

Adam MG, Berger C, Feldner A, Yang WJ, Wüstehube- Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG, Fischer A.
Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Circ Res. , 113:1206-1218. (Projects A3, A7)

Hollenbach M, Stoll SJ, Jörgens K, Seufferlein T, Kroll J.
Different regulation of physiological and tumor angiogenesis in zebrafish by protein kinase D1 (PKD1).
PLoS One. 8:e68033, 2013. (Project Z5)

Schumacher D, Strilic B, Sivaraj KK, Wettschureck N, Offermanns S.
Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.
Cancer Cell, 24(1):130-7, 2013. (Project C7)

Stoll SJ, Bartsch S and Kroll J.
HOXC9 Regulates Formation of Parachordal Lymphangioplasts and the Thoracic Duct in Zebrafish via Stabilin 2.
PLoS One, 2013;8(3):e58311. doi: 10.1371/journal.pone.0058311. Epub 2013 Mar 6. (Z5)

Pappelbaum KI, Gorzelanny C, Grassle S, Suckau J, Laschke MW, Bischoff M, Bauer C, Schorpp-Kistner M, Weidenmaier C, Schneppenheim R, Obser T, Sinha B, Schneider SW.
Ultralarge von Willebrand factor fibers mediate luminal Staphylococcus aureus adhesion to an intact endothelial cell layer under shear stress.
Circulation 128(1):50-9, 2013. (Project A9)

Chen H, Fallah MA, Huck V, Angerer JI, Reininger AJ, Schneider SW, Schneider MF, Alexander-Katz A.
Blood-clotting-inspired reversible polymer-colloid composite assembly in flow.
Nat Commun.4:1333, 2013. (Project A9)



Kaluza D, Kroll J, Gesierich S, Manavski Y, Boeckel JN, Doebele C, Zelent A, Rössig L, Zeiher AM, Augustin HG, Olson EN, Urbich C, Dimmeler S.
HDAC9 promotes angiogenesis by targeting the anti-angiogenic miR-17-92 cluster in endothelial cells.
Arterioscler Thromb Vasc Biol 2012, in press (A2, A3, B5, Z5).

Althoff TF, Albarrán Juárez J, Troidl K, Tang C, Wang S, Wirth A, Takefuji M, Nina Wettschureck N, and Offermanns S.
Procontractile G protein–mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling.
J. Exp. Med. 2012, in press (C7).

Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DYR, Srivastava D.
miR-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting VEGF signaling.
Circ Res. 2012, in press (Z5, A3).

Liebler SS, Feldner A, Adam MG, Korff, T, Augustin HG, Fischer A.
No evidence for a functional role of bi- directional Notch signaling during angiogenesis.
PloS one. 7:e53074, 2012 (A7, A3, C5).

Géraud C*, Evdokimov K*, Straub BK, Peitsch WK, Demory A, Dorflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S.
Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PloS one. 7: e34206, 2012 (A3, B1).

Carbajo-Lozoya J, Lutz S, Feng Y, Kroll J, Hammes HP, Wieland T.
Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium. Cell Signal. Jun;24(6): 1261-9, 2012 (B6, Z5).

Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG.
Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.
J Clin Invest, 1;122(6):1991-2005, 2012 (A2, A3, B1, B6)

Desch A, Strozyk EA, Bauer AT, Huck V, Niemeyer V, Wieland T, Schneider SW.
Highly Invasive Melanoma Cells Activate the Vascular Endothelium via an MMP-2/Integrin ανβ5-Induced Secretion of VEGF-A.
Am J Pathol, May 2012, in press (A9, B6)

Randriamboavonjy V, Fleming I.
All cut up! The consequences of calpain activation on platelet function.
Vasc Pharmacol, 56:210-5., 2012 (A6)

Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, and Hecker M.
Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells.
Cardiovascular Research, 94, 510–518, 2012 (A3, C1, C5, C6)

Frömel T, Jungblut B, Hu J, Trouvain C, Barbosa-Sicard E, Popp R, Liebner S, Dimmeler S, Hammock BD, Fleming I.
Soluble epoxide hydrolase regulates hematopoietic progenitor cell function via generation of fatty acid diols.
Proc Natl Acad Sci USA, 109:9995-10000, 2012(A2, A6, B7)

Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz K, Boon R, Bonauer A, Döbele C, Böckel JN, Hergenreider E, Zeiher AM, Kroll J, Fleming I, and Dimmeler S.
MicroRNA-27a/b controls repulsion and angiogenesis by targeting semaphorin 6A in endothelial cells.
Cell Death Dis 119:1607-1616, 2012(A2, A6, B5, Z5).

Niland S, Eble JA.
Integrin-mediated interaction in physiological and pathological blood vessel formation. J Oncology, 125278, 2012 (A8)

Walter BM, Nordhoff C, Varga G, Goncharenko G, Schneider SW, Ludwig S, Wixler V.
Mss4 protein is a regulator of stress response and apoptosis.
Blood. Apr; 12;3:e297. doi: 10.1038/cddis.2012.37, 2012 (A9)

Pfreimer M, Vatter P, Langer T, Wieland T, Gierschik P, Moepps B. .
LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways.
Cell Signal, Mar;24(3):652-63, 2012(B6)



Loot AE, Fleming I. Cytochrome P450-derived epoxyeicosatrienoic acids and pulmonary hypertension: central role of transient receptor potential (TRP) C6 channels.
J Cardiovasc Pharmacol, 257:140-7, 2011 (A6)

Schledzewski K*, Géraud C*, Arnold B, Wang S, Grone HJ, Kempf T, Wollert KC, Straub BK, Schirmacher P, Demory A, Schonhaber H, Gratchev A, Dietz L, Thierse HJ, Kzhyshkowska J, Goerdt S.
Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.
The Journal of clinical investigation 121: 703-714, 2011 (B1)

Scholz A, Lang V, Henschler R, Czabanka M, Vajkoczy P, Chavakis E, Drynski J, Harter PN, Mittelbronn M, Dumont DJ, Plate KH, Reiss Y.
Angiopoietin-2 promotes myeloid cell infiltration in a {beta}2 integrin-dependent manner.
Blood. 118(18), 2011 (A2, C1)

Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, Urbich C.
Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin.
EMBO J. 30: 4142–4156, 2011 (A2, A3, B5, Z5).

Wagner TU*, Fischer A*, Thoma E, Schartl M.
CrossQuery: a web tool for easy associative querying of transcriptome data.
PLoS One. 6(12):e28990, 2011 (A7)

Lonsdorf AS, Krämer BF, Fahrleitner M, Schönberger T, Gnerlich S, Ring S, Gehring S, Schneider SW, Kruhlak MJ, Meuth SG, Nieswandt B, Gawaz M, Enk AH, Langer HF.
Engagement of αIIbb3 (GPIIb/IIIa) with ανb3 mediates interaction of melanoma cells with platelets – a connection to hematogenous metastasis.
J Biol Chem. (A9)

Feldner A, Otto H, Rewerk S, Hecker M, Korff T.
Experimental hypertension triggers varicosis-like maladaptive venous remodeling through activator protein-1.
FASEB J.Oct;25(10):3613-21. Epub 2011 Jun 17, 2011(collaboration C5, C6)

Kempkes C, Rattenholl A, Buddenkotte J, Strozyk E, Eberle J, Hausser A, Cevikbas F, Schneider SW, Steinhoff M
Proteinase-activated receptors 1 and 2 regulate invasive behaviour of human melanoma cells via activation of protein kinase D1.
J Invest Dermatol. Oct;132(2):375-84, 2011 (A9)

Coffelt SB, Chen YY, Muthana M, Welford AF, Tal AO, Scholz A, Plate KH, Reiss Y, Murdoch C, De Palma M, Lewis CE.
Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion. Journal of Immunology. 186(7), 2011 (C1)

Fleming I.
Cytochrome P450-dependent eicosanoid production and cross-talk.
Curr Opin Lipidology. 22:403-9, 2011 (A6)

Brenneis C, Sisignano M, Coste O, Altenrath K, Fischer M, Angioni C, Fleming I, Brandes R, Reeh P, Woolf C, Geisslinger G, Scholich K.
Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation.
Mol Pain. 7:78, 2011 (A6)

Wagner AH, Hildebrandt A, Baumgarten S, Jungmann A, Müller OJ, Sharov VS, Schöneich C, Hecker M.
Tyrosine nitration limits stretch-induced CD40 expression and disconnects CD40 signaling in human endothelial cells.
Blood Sep 29;118(13):3734-42, 2011(C6).

Müller H, Hu J, Popp R, Schmidt MH, Müller-Decker K, Möllenhauer J, Fisslthaler B, Eble JA, Fleming I.
Deleted in malignant brain tumors 1 (DMBT1) is present in the vascular extracellular matrix and promotes angiogenesis
Arterioscl Throm Vas Biol . 32: 442-448, 2011 (A6, A8)

Sander A, Jakob H, Sommer K, Sadler C, Fleming I, Marzi I, Frank J.
Cytochrome P450-derived epoxyeicosatrienoic acids accelerate wound epithelialization and neovascularization in the hairless mouse ear wound model.
Langenbeck's Arch Surg. 396:1245-53, 2011 (A6)

Bauer AT, Strozyk EA, Gorzelanny C, Westerhausen C, Desch A, Schneider MF, Schneider SW.
Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells
Biomaterials. Aug; 32(33):8385-93, 2011 (A9)

Stoll SJ, Bartsch S, Augustin HG, Kroll J.
The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8.
Circ Res. April 14, 2011 (Z5, A3).

Schleider E, Stahl S, Wüstehube J, Walter U, Fischer A, Felbor U.
Evidence for anti-angiogenic and pro-survival functions of the cerebral cavernous malformation protein 3.
Neurogenetics Feb;12(1):83-6, 2011 (A7).

Hahn S, Achenbach J, la Buscató-Arsequell E, Klingler F, Hieke M, Dittrich M, Zettl H, Schroeder M, Meirer K, Hering J, Barbosa-Sicard E, Löhr F, Fleming I, Doetsch V, Schubert-Zilavecz M, Steinhilber D, Proschak E.
Inhibitors of phosphatase activity of soluble epoxide hydrolase found by in silico and in vitro fragment-based screening.
Chem Med Chem. 6:2146-9, 2011 (A6)

Niland S, Westerhausen C, Schneider SW, Eckes B, Schneider MF, Eble JA
Biofunctionalization of a generic collagenous triple helix with the α2β1 integrin binding site allows molecular force measurements.
Int J Biochem Cell Biol. Jan43(5):721-31, 2011 (A6, A9).

Fleming I.
The cytochrome P450 pathway in angiogenesis and endothelial cell biology.
Cancer Metastasis Rev. 30:541-55, 2011 (A6)



Petri B, Broermann A, Li H, Khandoga AG, Zarbock A, Krombach F, Goerge T, Schneider SW, Jones C, Nieswandt B, Wild MK, Vestweber D
Von Willebrand factor promotes leukocyte extravasation.
Blood Nov. 116(22):4712-9, 2010 (A9)

Wuertz CM, Lorincz A, Vettel C, Thomas MA, Wieland T, Lutz S.
p63RhoGEF--a key mediator of angiotensin II-dependent signaling and processes in vascular smooth muscle cells.
FASEB J.Dec;24(12):4865-76, 2010 (B6)

Kerk N, Strozyk E, Pöppelmann B, Schneider SW
Mechanism of Melanoma-Associated Thrombin Activity and von Willebrand Factor Release from Endothelial Cells.
J Invest Dermatol. Sep. 130(9):2259-68, 2010 (A9)

Géraud C*, Schledzewski K*, Demory A, Klein D, Kaus M, Peyre F, Sticht C, Evdokimov K, Lu S, Schmieder A, Goerdt S.
Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1.
Hepatology 52: 313-326, 2010 (B1)

Revermann M, Schloss M, Barbosa-Sicard E, Mieth A, Liebner S, Morisseau C, Geisslinger G, Schermuly RT, Fleming I, Hammock BD, Brandes RP.
Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice.
Arterioscler Thromb Vasc Biol. 30:909-14, 2010 (A6)

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M.
Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice.
J Clin Invest. Jul 1;120(7):2307-18, 2010 (collaboration A3, B2, C5, C6).

Coffelt SB, Tal AO, Scholz A, De Palma M, Patel S, Urbich C, Biswas SK, Murdoch C, Plate KH, Reiss Y, Lewis, CE.
Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.
Cancer Research. 70(13), 2010 (B5, C1)

Campbell WB, Fleming I.
Epoxyeicosatrienoic acids and endothelium-dependent responses.
Pflüger's Arch Eur J Pharmacol. 459:881-95, 2010 (A6)

Sanchez EF, Schneider FS, Yarleque A, Borges MH, Richardson M, Figueiredo Gomes S, De Santana Evangelista K, Eble JA.
The novel metalloproteinase, atroxlysin-I, from Peruvian Bothrops atrox (Jergón) snake venom acts on blood vessel ECM and platelets.
Arch Biochem Biophys. 496: 9-20, 2010 (A6)

Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A.
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.
Proc Natl Acad Sci U S A. Jul 13;107(28):12640-5, 2010 (A3, A7)

Bioulac-Sage P, Lepreux S, Schledzewski K, Cubel G, Géraud C, Goerdt S, Balabaud C.
Identification of liver sinusoidal endothelial cells in the human liver.
Liver International. 30: 773-776, 2010 (B1)

Doebele C, Bonauer A, Fischer A, Scholz A, Reiss Y, Urbich C, Hofmann W-K, Zeiher AM, Dimmeler S.
Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells.
Blood. 115(23), 2010 (A2, A7, B5, C1)

Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A.
Integrin Cytoplasmic Domain-Associated Protein-1 Attenuates Sprouting Angiogenesis.
Circ Res. Jul 8, 2010 [Epub ahead of print] (A3, A7)

Schäfer A, Fraccarollo D, Galuppo P, Vogt C, Widder J, Pfrang J, Tas P, Barbosa-Sicard E, Ruetten H, Ertl G, Fleming I, Bauersachs J.
Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation.
Diabetes. 59:2001-9, 2010 (A6)

Reiss, Y.
Recent Results Cancer Res. 180, 3-13, 2010 (C1)

Fallah MA, Myles VM, Krüger T, Sritharan K, Wixforth A, Varnik F, Schneider SW*, Schneider MF.
Melanoma cell adhesion on von Willebrand Factor coated µ-fluidic channels.
Biomicrofluidics. (*corresponding author) May 19;4(2). pii: 024106, 2010 (A9)

Epting D, Wendik B, Bennewitz K, Dietz CT, Driever W, Kroll J.
The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish.
Circ Res. May 13, 2010 (Z5)

Liebner S, Plate KH.
Differentiation of the brain vasculature: the answer came blowing by the Wnt.
J Angiogenes Res. Jan 14;2:1, 2010 (B7)

Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T.
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
Cancer Res. Jan 1;70(1):357-66, 2010. Epub 2009 Dec 22.

Keserü B, Barbosa-Sicard E, Schermuly RT, Tanaka H, Hammock BD, Weissmann N, Fisslthaler B, Fleming I.
Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition.
Cardiovasc Res. Jan 1;85(1):232-40. Epub, 2010 (A6)

Beck H, Raab S, Copanaki E, Heil M, Scholz A, Shibuya M, Deller T, Machein M, Plate KH.
VEGFR-1 Signaling Regulates the Homing of Bone Marrow-Derived Cells in a Mouse Stroke Model.
J Neuropathol Exp Neurol. Jan 13. [Epub ahead of print], 2010 (C1 former C4).



Hermann M, Hellermann JP, Quitzau K, Hoffmann MM, Gasser T, Meinertz T, Münzel T, Fleming I, Lüscher TF.
CYP4A11 polymorphism correlates with coronary endothelial dysfunction in patients with coronary artery disease--the ENCORE Trials.
Atherosclerosis. Dec;207(2):476-9, 2009(A6)

Carmona G, Göttig S, Orlandi A, Scheele J, Bäuerle T, Jugold M, Kiessling F, Henschler R, Zeiher AM, Dimmeler S, Chavakis E
Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis.
Blood. 113: 488-97, 2009 (A2, Z1)

Revermann M, Barbosa-Sicard E, Dony E, Schermuly RT, Morriseau C, Geisslinger G, Fleming I, Hammock BD, Brandes RP.
Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats.
J Hypertension. 27:322-331, 2009 (A6)

de Santana Evangelista K, Andrich F, Figueiredo de Rezende F, Niland S, Cordeiro MN, Horlacher T, Castelli R, Schmidt-Hederich A, Seeberger PH, Sanchez EF, Richardson M, Gomes de Figueiredo S, Eble JA.
Plumieribetin, a fish lectin homologous to mannose-binding B-type lectins, inhibits the collagen-binding alpha1beta1 integrin.
J Biol Chem. Dec 11;284(50):34747-59, 2009 (A8)

Limbourg A, Korff T, Napp LC, Schaper W, Drexler H, Limbourg FP.
Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia.
Nat Protoc. 4(12):1737-46, 2009 (C5)

Zigrino P, Kuhn I, Bäuerle T, Zamek J, Fox JW, Neumann S, Licht A, Schorpp-Kistner M, Angel P, Mauch C.
Stromal expression of MMP-13 is required for melanoma invasion and metastasis.
J Invest Dermatol. Nov;129(11):2686-93, 2009 (collaboration B2, Z1)

Wagner AH, Kautz O, Fricke K, Zerr-Fouineau M, Demicheva E, Güldenzoph B, Bermejo JL, Korff T, Hecker M.
Upregulation of glutathione peroxidase offsets stretch-induced proatherogenic gene expression in human endothelial cells.
Arterioscler Thromb Vasc Biol. Nov;29(11):1894-901, 2009(collaboration C5, C6)

Zhang J, Gratchev A, Riabov V, Mamidi S, Schmuttermaier C, Krusell L, Kremmer E, Workman G, Sage EH, Jalkanen S, Goerdt S, Kzhyshkowska J.
A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1.
Mol Cell Biol. Nov;29(22):6097-105, 2009 (B1)

Barbosa-Sicard E, Frömel T, Keserü B, Brandes RP, Morisseau C, Hammock BD, Braun T, Krüger M, Fleming I.
Inhibition of the soluble epoxide hydrolase by tyrosine nitration.
J Biol Chem. Oct 9;284(41):28156-63, 2009 (A6)

Bäuerle T, Semmler W.
Imaging response to systemic therapy for bone metastases.
Eur Radiol. Oct;19(10):2495-507, 2009 (Z1)

Franco CA, Liebner S, Gerhardt H.
Vascular morphogenesis: a Wnt for every vessel?
Curr Opin Genet Dev. Oct;19(5):476-83, 2009 (B7)

Wickersheim A, Kerber M, de Miguel LS, Plate KH, Machein MR.
Endothelial progenitor cells do not contribute to tumor endothelium in primary and metastatic tumors.
Int J Cancer. Oct 15;125(8):1771-7, 2009 (C1)

Laib AM, Bartol A, Alajati A, Korff T, Weber H, Augustin HG.
Spheroid-based human endothelial cell microvessel formation in vivo.
Nat Protoc. 4(8):1202-15, 2009 (collaboration A3, C5)

Eble JA, Niland S, Bracht T, Mormann M, Peter-Katalinic J, Pohlentz G, Stetefeld J.
The alpha2beta1 integrin-specific antagonist rhodocetin is a cruciform, heterotetrameric molecule.
FASEB J. Sep;23(9):2917-27, 2009 (A8)

Mirko H.H. Schmidt, Frank Bicker, Iva Nikolic, Jeannette Meister, Tanja Babuke, Srdjan Picuric, Werner Müller-Esterl, Karl H. Plate and Ivan Dikic
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.
Nature Cell Biology Jul;11(7):873-80, 2009 (A4)

Gassmann P, Haier J, Schlüter K, Domikowsky B, Wendel C, Wiesner U, Kubitza R, Engers R, Schneider SW, Homey B, Müller A.
CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.
Neoplasia. Jul;11(7):651-61, 2009 (A9)

Wittko IM, Schänzer A, Kuzmichev A, Schneider FT, Shibuya M, Raab S, Plate KH.
VEGFR-1 regulates adult olfactory bulb neurogenesis and migration of neural progenitors in the rostral migratory stream in vivo.
J Neurosci. Jul 8;29(27):8704-14, 2009 (C1)

Kuhn M, Völker K, Schwarz K, Carbajo-Lozoya J, Flögel U, Jacoby C, Stypmann J, van Eickels M, Gambaryan S, Hartmann M, Werner M, Wieland T, Schrader J, Baba HA.
The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice.
J Clin Invest. Jul;119(7):2019-30, 2009 (B6)

Benest AV, Augustin HG.
Tension in the vasculature.
Nat Med. Jun;15(6):608-10, 2009 (A3)

Urbich C, Rössig L, Kaluza D, Potente M, Boeckel JN, Knau A, Diehl F, Geng JG, Hofmann WK, Zeiher AM, Dimmeler S.
HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells.
Blood. May 28;113(22):5669-79, 2009 (collaboration B5, A2)

Herroeder S, Reichardt P, Sassmann A, Zimmermann B, Jaeneke D, Hoeckner J, Hollmann MW, Fischer KD, Vogt S, Grosse R, Hogg N, Gunzer M, Offermanns S, Wettschureck N.
Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility.
Immunity. May;30(5):708-20, 2009 C7)

Thomas M, Augustin HG.
The role of the Angiopoietins in vascular morphogenesis.
Angiogenesis. 12(2):125-37, 2009 (A3)

Klein D, Demory A, Peyre F, Kroll J, Géraud C, Ohnesorge N, Schledzewski K, Arnold B, Goerdt S.
Wnt2 acts as an angiogenic growth factor for non-sinusoidal endothelial cells and inhibits expression of stanniocalcin-1.
Angiogenesis. 12(3):251-65, 2009 (collaboration B1, Z5)

Augustin HG, Koh GY, Thurston G, Alitalo K.
Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.
Nat Rev Mol Cell Biol. Mar;10(3):165-77, 2009 Review (A3)

Reiss Y , Knedla A, Tal AO, Schmidt MH, Jugold M, Kiessling F, Burger AM, Wolburg H, Deutsch U, Plate KH.
Switching of vascular phenotypes within a murine breast cancer model induced by angiopoietin-2.
J Pathol. Mar;217(4):571-80, 2009 (C1)

Kroll J, Epting D, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, Augustin HG.
Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis.
Am J Physiol Heart Circ Physiol. Mar;296(3):H893-9, 2009 (A3, B6, Z5)

Helfrich I, Edler L, Sucker A, Thomas M, Christian S, Schadendorf D, Augustin HG.<
Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.
Clin Cancer Res. Feb 15;15(4):1384-92, 2009 (A3)

Korhonen H, Fisslthaler B, Moers A, Wirth A, Habermehl D, Wieland T, Schütz G, Wettschureck N, Fleming I, Offermanns S.
Anaphylactic shock depends on endothelial Gq/G11.
J Exp Med. Feb 16;206(2):411-20, 2009 (collaboration A6, B6, C7)

Nasarre P, Thomas M, Kruse K, Helfrich I, Wolter V, Deppermann C, Schadendorf D, Thurston G, Fiedler U, Augustin HG.
Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth.
Cancer Res. Feb 15;69(4):1324-33, 2009 (A3)

Fiedler LR, Eble JA. Decorin regulates endothelial cell-matrix interactions during angiogenesis.
Cell Adh Migr. Jan 24;3(1)2009 (A8)

Eble JA, Niland S. The extracellular matrix of blood vessels.
Curr Pharm Des. 15(12):1385-400, 2009 Review (A8)

Eble JA.
The extracellular matrix in health and disease.
Curr Pharm Des. (A8)


Last update: April 2017