SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

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Prof. Dr. Markus Hecker

University of Heidelberg
Institute of Physiology and Pathophysiology
Division of Cardiovascular Physiology

Im Neuenheimer Feld 326
D-69120 Heidelberg

Phone: 0049 (0)6221 54 4035

Lab Homepage

C6: Endothelial cell-platelet-leukocyte interactions during vascular remodeling
By combining different mouse models with state of the art imaging and protein detection methods, we will verify the in vivo relevance of the CD154-induced ultra-large von Willebrand factor (ULVWF) multimer- mediated endothelial cell-platelet-monocyte/macrophage crosstalk in adaptive and maladaptive vascular remodeling processes. We will further detail the conditions favoring deposition of these ULVWF strings on the endothelial cell surface, and explore the impact of a genetic defect in endothelial cell nitric oxide formation on this multicellular crosstalk orchestrated through repeated CD40-CD154 costimulation.

Last update: July 2013