SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Prof. Dr. Ingrid Fleming Institute for Vascular Signalling Centre for Molecular Medicine Goethe University Theodor Stern-Kai 7 D-60590 Frankfurt Phone: 0049 (0)69 6301 6972 or -6052 Lab Homepage
	fleming(at)em.uni-frankfurt.de
A6: The Cytochrome P450/ soluble epoxide hydrolase axis in angiogenic endothelial cell signalling and vascular differentiation
The major aims of this project are to clarify the mechanisms underlying angiogenesis and vascular stabilization by the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) axis. To achieve these goals we plan to concentrate on the signalling (Notch, Wnt, G protein-coupled receptors) initiated by bioactive fatty acids (CYP-derived epoxides and sEH-derived diols) generated/metabolized by three enzyme families, namely; the CYP epoxygenases Cyp2c44 and CYP2S1 as well as the sEH.