SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Prof. Dr. Stefan W. Schneider Universitätsmedizin Mannheim Klinik für Dermatologie Sektion Experimentelle Dermatologie Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim Phone: 0049 (0) 621 383 1643 Lab Homepage
	Stefan.Schneider(at)umm.de
A9: Mechanism controlling the transition from quiescent to activated endothelium by exocytosis of Weibel-Palade bodies triggered by tumor cells
Endothelial cell (EC) activation is a prerequisite for tumor spreading and angiogenesis. One initial step of EC activation includes the exocytosis of Weibel-Palade bodies (WPBs), followed by the release of the procoagulatory protein von Willebrand factor (VWF) and inflammatory cytokines. Although WPBs are also present in lymphatic ECs (LEC), their regulation, function and composition are unknown. This proposal focuses on tumor cell-induced WPB exocytosis in ECs (including LECs), VWF release and its impact on tumor cell adhesion and spreading within the lymphatic vessels.