SFB / Transregio 23
"Vascular Differentiation and Remodeling"

Mannheim - Heidelberg - Frankfurt

Dr. Andreas Fischer Vascular Biology, Center for Biomedicine and Medical Technology (CBTM), Medical Faculty Mannheim, Heidelberg University Ludolf-Krehl-Str. 13-17 D-68167 Mannheim Phone: 0049 (0)621 383 9963 Lab Homepage
	andreas.fischer(at)medma.uni-heidelberg.de
A7: The role of Notch ligands during blood vessel development
The Delta-Notch pathway is crucial for the development and differentiation of blood vessels. Yet, constitutive Notch signaling is also needed to maintain vascular barrier functions and the quiescent, resting endothelial phenotype. We have identified several modifiers of Notch ligands, like the multiple PDZ domain protein MPDZ. We aim at deciphering molecular and cellular functions how MPDZ and Notch signaling keep blood vessels fully functional throughout life.

Delta-Notch signaling:Interaction of Notch receptors with ligands induces cleavage of the receptor
leading to liberation of the intracellular domain followed by induction of target genes like Hes and Hey.